围产期暴露于破坏甲状腺功能的环境化学物质,可能会扰乱丸发育
Monica K Draskau1, Ida W Strand1, Raul Ayala Davila2
1National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.
Environmental pollution (Barking, Essex : 1987)
|October 16, 2024
概括
周产期暴露于除草剂阿米或抗甲状腺药物甲基马 (MMI) 在发育大鼠中降低了甲状腺激素 (THs). 这种干扰损害了丸的发育,影响了胚胎和塞尔托利细胞,并引起了生殖健康的担忧.
科学领域:
- 内分泌学 在内分泌学.
- 生殖毒理学 生殖毒理学
- 发展生物学 发展生物学
背景情况:
- 甲状腺激素 (THs) 对于哺乳动物的生长和发育至关重要,特别影响骨和大脑的成熟.
- 发育性甲状腺功能低下症可能导致丸异常,包括较小的丸和改变的塞尔托利细胞增殖.
- 破坏甲状腺激素合成的环境化学物质可能对生殖健康构成风险.
研究的目的:
- 研究围产期暴露于除草剂阿米和抗甲状腺药物甲基马 (MMI) 对大鼠丸发育的影响.
- 评估这些暴露对甲状腺激素水平和丸组织学的影响.
- 为了检查暴露后胎儿男性的荷尔蒙变化.
主要方法:
- 怀孕的斯普拉格 - 达利大鼠从妊娠7天到出生时暴露在阿米特罗尔 (25或50毫克/公斤/天) 或MMI (8或16毫克/公斤/天),并通过哺乳母继续暴露在幼中,直到出生后的16天.
- 甲状腺激素水平测量是在产后16天.
- 在幼中评估了丸参数,包括大小和精卵管直径.
- 分析了胎儿血液中的男性激素水平 (孕激素,雌激素).
主要成果:
- 阿米和MMI都显著降低了16日幼的甲状腺激素水平.
- 对这两种药物的周产期暴露导致16天大的幼的丸变小,精管直径减少,这表明细菌和塞尔托利细胞发育受到干扰.
- 暴露于这两种化学物质会增加胎儿男性血液中的孕激素水平.
- 阿米暴露也导致胎儿男性雌激素水平的增加.
结论:
- 周产期暴露于阿米或MMI会诱导甲状腺功能低下症,对大鼠的雄性生殖器官发育产生不利影响.
- 抑制甲状腺激素产生的环境化学物质可能会破坏TH-依赖的丸发育.
- 这些发现凸显了环境内分泌干扰物对人类生殖健康的潜在风险.
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