一种新的共晶方法 celecoxib 与 piperine:同时提高溶解速率和压缩性
Lili Fitriani1, Fauziyyah Dirfedli1, Yori Yuliandra2
1Department of Pharmaceutics, Faculty of Pharmacy, Andalas University, Padang 25163, Indonesia.
Journal of pharmaceutical sciences
|October 16, 2024
概括
这项研究开发了一种新型的赛莱科克西布-皮佩林共晶体,增强了赛莱科克西布的溶解和压缩性. 这种共晶为非类固醇抗炎药物 (NSAIDs) 提供了改善的药物递送特性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 切莱科西布是一种选择性COX-2抑制剂NSAID,具有较差的水溶和压缩性.
- 来自Piper nigrum L.的皮佩林与塞莱科克西布有共同的止痛和抗炎性质.
- 改善赛莱科克西布的物理化学特性对于有效的药物配方至关重要.
研究的目的:
- 为了合成和表征一个celecokxib-piperine联合晶体.
- 为了提高赛莱可西布的溶解率和压缩性.
- 为了研究共晶体在改善药物配方方面的潜力.
主要方法:
- 通过播种方法合成晶.
- 使用粉末X射线衍射 (PXRD),差分扫描热度计 (DSC) 和红外光谱光度计 (FT-IR) 的表征.
- 单晶X射线衍射用于结构确认.
- 内部溶解试验和平板电脑压缩研究用于性能评估.
主要成果:
- 通过PXRD,DSC和FT-IR证实了赛莱科西布-皮佩林共晶的成功形成.
- 单晶XRD验证了一种等极共晶结构.
- 与单独使用赛莱科克西布相比,观察到溶解速率略有增加和压缩性显著改善.
- 增强的物理机械性能归因于共晶的晶格结构.
结论:
- 一种新型的赛莱科克西布-皮佩林共晶成功制备.
- 与纯粹的塞莱科克西布相比,共晶体表现出更好的溶解和压缩性.
- 这种共晶体代表了一种增强NSAID配方和输送的有前途的方法.
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