童年不良经历与怀孕患病之间的关联:全国性的基于在线的截面研究
Yuto Maeda1, Takahiro Tabuchi2, Takeo Fujiwara1
1Department of Public Health, Institute of Science Tokyo, Bunkyo-ku, Tokyo, Japan.
The journal of obstetrics and gynaecology research
|October 16, 2024
概括
童年不良经历 (ACE) 与日本妇女早产,孕前和妊娠糖尿病风险增加有关. 小的孕期年龄与ACE没有关联.
科学领域:
- 生殖健康 生殖健康
- 围产期流行病学 围产期流行病学
- 童年创伤研究 童年创伤研究
背景情况:
- 儿童不良经历 (ACE) 被认为是长期健康结果的重要决定因素.
- ACE 对怀孕发病率的影响需要进一步研究,特别是在不同人群中.
- 了解这些关联对于开发有针对性的干预和支持系统至关重要.
研究的目的:
- 调查日本各种ACE与特定怀孕疾病之间的关联.
- 为了确定ACE数量和不良妊娠结果之间是否存在剂量反应关系.
- 为了确定与童年逆境相关的特定妊娠并发症.
主要方法:
- 利用了来自JACSIS研究的数据,这是一项在日本进行的在线全国性调查 (N=5444).
- 评估的ACE包括虐待,忽视,贫困,欺凌,家庭暴力,父母死亡和离婚.
- 采用多变量逻辑回归来分析ACE与怀孕疾病 (PTB,GDM,孕前,SGA) 之间的关系.
主要成果:
- 在总ACE得分和早产和孕前之间观察到剂量反应相关性.
- 四个或更多的ACE显著增加了孕前的风险 (aOR:3.06).
- 过早分娩 (aOR:1.42-1.61) 和妊娠糖尿病 (aOR:1.34) 的风险增加与特定的ACE数量有关,而较小的妊娠年龄与ACE数量没有关联.
结论:
- 在日本人口中,不良的童年经历与早产,孕前和妊娠期糖尿病的风险更高有关.
- 这些发现突显了童年逆境对母亲和婴儿健康的持久影响.
- 进一步的研究和针对ACE的预防策略是有必要的,以改善妊娠结果.
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