通道阻塞剂对流感发病率的影响:基于人口的回顾性队列研究,使用日本的行政索赔数据
Takanori Imai1, Hideki Hashimoto1,2, Naoki Kanda1
1Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan.
BMJ open
|October 16, 2024
概括
与高血压患者的ACEI/ARB相比,通道阻断剂 (CCB) 在预防流感方面没有显著差异. 需要进一步的研究来确认CCBs.
科学领域:
- 病毒学和传染病学.
- 心血管药理学心血管药理学
- 流行病学和公共卫生.
背景情况:
- 实验室研究表明,通道阻断剂 (CCB) 抑制了流感A病毒的复制.
- 缺乏关于CCB使用和患者流感发病率的临床证据.
- 高血压管理通常涉及CCB或ACEI/ARB.
研究的目的:
- 调查CCB使用与高血压患者流感发病率之间的关联.
- 在日本,为了比较患者的流感发病率,医生处方了CCB与ACEI/ARB.
主要方法:
- 使用来自日本熊本县 (2012-2016) 的行政索赔数据进行的回顾性队列研究.
- 包括高血压患者在内,他们被处方了CCB (N=360,515) 和ACEI/ARB (N=171,142).
- 高维倾向分数 (HD-PS) 与混因素的控制匹配.
主要成果:
- 分析了166,814个匹配的对.
- 在CCB和ACEI/ARB组之间没有观察到流感发病率的显著差异,HD-PS后的匹配 (2.4%对2.5%,p=0.067).
- 在CCB组中,只有在2012年才注意到流感发病率显著降低.
结论:
- 与高血压患者的ACEI/ARB使用相比,CCB的使用与流感发病率没有显著不同.
- 需要进一步的直接比较研究来最终评估CCB在减少流感发病率方面的潜在作用.
- 这些发现凸显了对体外观察结果的临床验证的需要.
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