与腹膜透析相关的Listeria monocytogenes腹膜炎被用静脉内和腹膜内两种药物治疗
Scott MacKay1, Benjamin W Ewanchuk1, Mark McIsaac2
1University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada.
BMJ case reports
|October 16, 2024
概括
李斯特菌单细胞原体腹膜炎是腹膜透析患者罕见但严重的感染. 成功的治疗涉及内和静脉注射安培西林的组合,随后是口服阿莫西西林.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 李斯特菌 (Listeria monocytogenes) 是一种机会性病原体,会影响免疫力低下的人.
- 与腹膜透析相关的L. monocytogenes腹膜炎是一种罕见的疾病,死亡率很高 (17.3%).
- 长期免疫抑制会增加移植患者的敏感性.
研究的目的:
- 报告一例罕见的腹透析相关的L. monocytogenes腹炎的成功治疗.
- 根据文献审查,为抗微生物剂量和频率提供信息.
主要方法:
- 一个60多岁的女性患者进行腹膜透析和免疫抑制治疗的案例研究.
- 用腹膜内安皮西林,静脉注射安皮西林和口服阿莫西西林治疗.
- 对现有病例研究的文献综述,以指导治疗方案.
主要成果:
- 成功治疗L. monocytogenes腹膜炎,使用安培和阿莫西的21天疗程.
- 在此前推的抗微生物疗法中显示出可变性.
- 患者对处方的多模式抗生素治疗反应良好.
结论:
- 一个全面的抗生素治疗方案可以有效地治疗与腹膜透析相关的L. monocytogenes腹膜炎.
- 由于现有建议的变化,需要标准化治疗方案.
- 早期和适当的抗微生物干预对于患者的治疗结果至关重要.
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