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Updated: Jun 10, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

Published on: May 26, 2019

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辛科纳有机催化酶选择性氨基化对四分化血清作为三级胺基的有机催化酶选择性氨基化

Phathutshedzo Masithi1, Ashlyn D Bhana1, Gerhard A Venter1

  • 1Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7700, South Africa.

Organic letters
|October 16, 2024
PubMed
概括

这项研究引入了一种Cinchona-aminocatalyzed方法,用于酶选择性α-hydrazination,产生具有高产率和酶选择性超过98%的受保护的四分化蛋白质. 这些发现使有价值的性化合物的高效合成成为可能.

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
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