在肺部健康的一般人群中,胸部CT-derived lobar体积的参考公式
Jens T Bakker1,2, Ivan Dudurych3, Sharyn A Roodenburg1,2
1Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
European radiology
|October 16, 2024
概括
用健康人群的CT扫描建立了肺部和叶片体积的参考方程. 这些值有助于评估肺高通胀,并指导COPD等肺部疾病的治疗方法.
科学领域:
- 医学成像医学成像
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
背景情况:
- 肺部高通胀是COPD呼吸障碍的主要原因之一.
- 胸部CT扫描可以量化肺部膨胀.
- 为了进行准确的评估,需要对叶片体积和肺总体积的参考值.
研究的目的:
- 通过CT扫描来建立分叶体和肺总体 (TLV) 的参考方程.
- 为了帮助评估大叶高通胀.
- 为了支持有针对性的肺体积减小疗法.
主要方法:
- 在生命线成像 (ImaLife) 研究中利用了来自11,729名参与者 (年龄在45岁以上) 的CT扫描.
- 采用基于人工智能的算法 (LungSeg) 进行肺部和叶片体积测量.
- 排除了COPD,肺部疾病,吸烟史或极端年龄/身高的参与者作为主要分析;用于参考方程的线性回归.
主要成果:
- 包括7306名肺部健康的参与者 (平均年龄为60.3岁,43.6%是男性).
- 随着年龄和身高,肺部和叶片体积增加;男性的体积比女性更大 (根据身高进行调整).
- 吸烟者和有呼吸道阻塞的人比肺部健康的人显示出更大的体积,特别是在上叶.
结论:
- 建立了CT衍生TLV和lobar体积的参考方程,用于北欧血统的45-80岁的个人.
- 为肺体积提供了标准化的解释.
- 用于评估肺体积减小候选人,肺癌切除和限制性肺病.
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