多目标便DNA测试对于正常结肠镜检查后结肠直肠癌查的实用性
Abhinav K Rao1,2, Shivam Kalra3, Brett Van Leer-Greenberg4
1Department of Internal Medicine, Trident Medical Center, 9330 Medical Plaza Dr, North Charleston, SC, 29406, USA. abhirao.md@gmail.com.
Journal of gastrointestinal cancer
|October 16, 2024
概括
多目标便DNA (MT-sDNA) 测试可能是一个可行的结肠直肠癌查替代方案,以往正常结肠镜检查的患者. 该组的MT-sDNA阳性结果显示,在随访结肠镜检查时,晚期腺瘤的发生率为30%.
科学领域:
- 胃肠病学和消化系统健康
- 瘤学和癌症查 癌症查
- 诊断性绩效评估的诊断性绩效评估是如何进行的
背景情况:
- 多目标便DNA (MT-sDNA) 测试是针对平均风险个体的结直肠癌查工具.
- 对于那些在之前的正常检查后寻求替代方法来重复结肠镜检查的患者,MT-sDNA测试也会被考虑.
- 在有正常结肠镜史的患者中评估MT-sDNA测试性能对于完善查策略至关重要.
研究的目的:
- 评估MT-sDNA测试在患者之前正常结肠镜检查的诊断性能.
- 为了确定晚期腺瘤和结直肠癌的发病率,在正常结直肠镜检查后,患者的MT-sDNA测试呈阳性.
主要方法:
- 追溯队列研究涉及5827名45岁及以上的患者,来自初级保健机构.
- 纳入标准:在MT-sDNA测试日期之前进行记录的正常,高质量的结肠镜检查.
- 排除标准:高风险患者和以前负的MT-sDNA结果的患者.
主要成果:
- 248名患者先前进行了正常结肠镜检查;63名患者的MT-sDNA测试呈阳性.
- 在41名患者的随访结肠镜检查显示,12名 (30%) 患有晚期腺瘤;没有检测到结肠直肠癌.
- 与没有结肠镜检查的患者相比,先前结肠镜检查的患者表现出较少的腺瘤 (1.6vs2.4) 和晚期腺瘤 (1.4vs2.0).
结论:
- 在先前进行正常结肠镜检查的患者中,阳性MT-sDNA测试与晚期腺瘤的显著率 (30%) 相关.
- 对于有正常结肠镜史的人来说,MT-sDNA测试是一个潜在的合理的替代查选择.
- 进一步的研究可能会探索MT-sDNA在这个特定患者群体中的长期疗效和成本效益.
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