在轻度至重度的COVID-19中流行和持久的新发自抗体
August F Jernbom1, Lovisa Skoglund2, Elisa Pin2
1Division of Affinity Proteomics, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden. august.jernbom@scilifelab.se.
Nature communications
|October 16, 2024
概括
在SARS-CoV-2感染后出现新的自身抗体,持续超过一年. 这些自身抗体与严重的COVID-19和神经精神病症状有关,这表明病毒与分子模仿.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 自体抗体与COVID-19的病原发生有关.
- 在SARS-CoV-2感染后的新自身抗体的谱和动态尚未完全理解.
研究的目的:
- 为了研究SARS-CoV-2感染后新自身抗体的出现和特征.
- 探索自身抗体与COVID-19后神经精神病症状之间的关联.
- 识别潜在的机制,如分子模拟,驱动自身抗体的生产.
主要方法:
- 在16个月内对525名医疗保健工作者和COVID-19患者的自身抗体库进行分析.
- 利用了全蛋白质组和向蛋白质/质阵列.
- 在包括神经COVID患者在内的独立队列中进行皮层映射和验证.
主要成果:
- 在SARS-CoV-2感染后出现了针对多种抗原的流行新发自抗体,并持续至少12个月.
- 在严重的COVID-19后,观察到自身抗体患病率的增加.
- 不同的自身抗体与COVID-19后的神经精神症状有关,有证据表明与SARS-CoV-2 Spike glycoprotein融合的分子模仿.
结论:
- 感染SARS-CoV-2诱导了一个复杂而动态的自身抗体谱.
- 新的自身抗体与COVID-19的严重程度和长期后果有关,包括神经精神问题.
- 持续监测自身抗体库对于了解COVID-19后的情况至关重要.
相关概念视频
01:27Myocarditis II: Clinical features and Diagnostic Tests
2
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
2
01:29Autoimmune Disorders
392
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
392
01:20Myasthenia Gravis: Overview and Treatment
1.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.2K
01:17Gastritis-II: Pathophysiology
264
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
264