在接受手术干预的患者中,特征,发病率和死亡率的时间变化是因为额头骨狭窄而发生的
Hans T Due1, Jeppe K Petersen2, Daniel E Meulengracht2
1Rigshospitalet, Hjertecentret, Blegdamsvej 9, 2100, Copenhagen, Denmark. hansdue012@gmail.com.
Scientific reports
|October 16, 2024
概括
在丹麦,对关狭窄 (MS) 的手术干预在20年内下降,死亡率稳定. 患者的个人资料发生了转变,显示心力衰竭较少,但心房动率相似.
科学领域:
- 心脏病学 心脏病学
- 心脏外科手术 心脏外科手术
- 公共卫生 公共卫生
背景情况:
- 中心狭窄症 (MS) 是一种严重的心脏病,需要及时干预.
- 了解患者特征和结果的时间趋势对于优化护理至关重要.
- 丹麦全国性注册表为纵向健康研究提供了一个强大的平台.
研究的目的:
- 分析2001年至2021年丹麦患者人口统计学变化,手术干预率和三年内对膜狭窄症 (MS) 的死亡率.
- 为了确定伴随性疾病的趋势,如心力衰竭和心房动.
- 评估这些趋势对外科手术发病率和患者结局的影响.
主要方法:
- 对丹麦全国性登记处的回顾性分析,这些登记处的成年患者首次接受MS手术 (2001-2021年).
- 将数据分为不同的日历时期进行分层,用于趋势分析.
- 使用卡普兰-梅尔估计和多变量考克斯回归来评估死亡率和相关因素.
主要成果:
- 观察到MS手术干预的发病率显著下降,从每百万人年中的3.3例降至2.2例.
- 慢性心力衰竭患者的比例大幅下降 (54%至20%),心房的患病率保持稳定 (51%至46%).
- 手术干预后三年全因死亡率在历年期间保持稳定,在调整后的分析中没有发现显著差异.
结论:
- 尽管手术干预的发病率下降了对关狭窄,患者的个人资料已经演变,心力衰竭的负担减少.
- 在MS手术后,所有原因的死亡率在过去二十年中一直保持稳定.
- 这些发现突显了患者特征的变化以及丹麦MS手术干预的持续有效性.
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