在丹麦,查患有炎症性肠道疾病或高结直肠癌风险的参与者:一项队列研究
Signe Bülow Therkildsen1, Pernille Thordal Larsen1,2, Sisse Helle Njor3,4,5
1Department of Public Health Programmes, University Research Clinic for Cancer Screening, Randers Regional Hospital, Skovlyvej 15, 8930, Randers NØ, Denmark.
患有炎症性肠病 (IBD) 和高风险群体的人在使用便免疫化学测试 (FIT) 进行结直肠癌 (CRC) 查时,错误阳性结果的比率更高. 这导致不必要的结肠镜检查,表明需要更新查协议.
科学领域:
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 癌症查 癌症查
背景情况:
- 目前的结肠直肠癌 (CRC) 查指南建议患有炎症性肠病 (IBD) 和高风险个人不要参与.
- 尽管有建议,但很大一部分这些人参加了丹麦便免疫化学测试 (FIT) 查.
- 与平均风险人群相比,这些群体呈现出更高的积极FIT率.
研究的目的:
- 估计IBD和高风险个体中错误阳性查结果的风险.
- 为改善有关这些人群查参与的建议提供证据.
- 分析当前选实践对资源利用的影响.
主要方法:
- 追溯分析2014-2017年71,871名FIT阳性参与者,他们在3个月内接受了结肠镜检查.
- 在FIT后180天内,使用国家注册表确定了查结果.
- 在IBD/高风险个体和平均风险人群之间比较假阳性率.
主要成果:
- 共有26,591名参与者被确定为具有假阳性查结果.
- 与平均风险个体相比,患有IBD或高CRC风险的个体表现出明显更高的假阳性FIT结果风险.
- 该研究强调了大量的与查相关的结肠镜检查,这些检查是在因假阳性结果导致IBD或高CRC风险的患者身上进行的.
结论:
- 患有IBD和高CRC风险的个体具有来自FIT的假阳性查结果的风险较高.
- 当前的查方案可能会导致这些特定人群的结肠镜检查过度.
- 更新的查协议是必要的,以优化资源配置和CRC查计划中的患者管理.
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