测试和通过疫苗接种和感染获得的免疫力对马萨诸塞州小学和中学学生的COVID-19病例的影响
Westyn Branch-Elliman1,2,3, Melissa Zeynep Ertem4, Richard E Nelson5,6
1VA Boston Center for Healthcare Optimization and Implementation Research (CHOIR), Boston, MA, US. wbranche@bidmc.harvard.edu.
Communications medicine
|October 16, 2024
概括
马萨诸塞州的学校测试计划略有降低了COVID-19阳性率. 接种疫苗和先前感染的免疫力显著影响了2021-22学年在学校的SARS-CoV-2传播.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染病控制和控制传染病
背景情况:
- 2021-22学年在马萨诸塞州的学校进行了广泛的SARS-CoV-2测试和疫苗接种.
- 关于校内测试对K-12设置中的COVID-19病例的影响的研究有限.
研究的目的:
- 评估校内测试计划和人口免疫力对学生中SARS-CoV-2病例率的影响.
- 评估在小学,中学和高中测试策略的有效性.
主要方法:
- 这是一项回顾性队列研究,分析了来自2141所学校和65万多名学生的数据.
- 用于估计监督测试影响的概括估计方程和目标试验模拟.
- 随机效应线性回归模拟了免疫力和疫苗接种的影响.
主要成果:
- 在学校监测测试显示,阳性率的小但显著下降.
- 在三角洲变种激增期间,聚合测试阳性与社区发病率相关.
- 在Omicron期间,增加的人口免疫力扭转了这一趋势,较低的先前感染负担与较高的当前病率相关.
结论:
- 学校内测试计划在支持亲自学习方面是有效的.
- 疫苗接种或自然感染引起的人口免疫力是确定学校SARS-CoV-2传播动态的关键因素.
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