序列流:用于可视化部分顺序对齐的交互式Web应用程序
Krzysztof Zdąbłasz1, Anna Lisiecka1, Norbert Dojer2
1Institute of Informatics, University of Warsaw, Banacha 2, Warszawa, 02-097, Poland.
BMC genomics
|October 16, 2024
概括
序列流可视化部分顺序对齐 (POA) 使用交互式桑基图,解决生物信息学工具的差距. 这个Web应用程序增强了复杂序列数据的探索和分析.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 多重序列对齐 (MSA) 对进化和功能洞察至关重要.
- 部分顺序对齐 (POA) 为序列数据提供了一个基于图形的替代模型.
- 现有的POA可视化工具有限,阻碍了其更广泛的应用.
研究的目的:
- 为部分顺序对齐开发高效的可视化工具.
- 通过交互式探索来突出POA模型的优势.
- 为POA可视化提供可访问的基于Web和专注于开发者的解决方案.
主要方法:
- 开发了一款用于POA可视化的Web应用程序Sequence Flow.
- 通过SanKEY.js库使用Sankey图表实现POA可视化.
- 启用了交互功能,如片段选择和节点修改,用于对齐探索.
主要成果:
- 序列流呈现POA作为交互式桑基图.
- 该工具允许用户探索,修改和保存大型对齐的可视化.
- 即使对于广泛的数据集,也实现了令人满意的性能.
结论:
- 介绍了序列流和SanKEY.js作为基于Sankey图表的POA可视化工具.
- 为最终用户和开发人员提供了资源,以加强POA分析.
- 公开提供了Sequence Flow网络服务和SanKEY.js源代码.
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