Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Progression02:07

Tumor Progression

6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Bone marrow edema as an independent imaging predictor of dedifferentiated chondrosarcoma.

Journal of orthopaedic surgery and research·2026
Same author

Inhibition of cyclin-dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation.

Molecular oncology·2026
Same author

Staged Resection with Temporizing VAC and Local Recurrence for Soft Tissue Sarcomas: A Multi-Institutional Review.

Cancers·2026
Same author

Systems-level analysis identifies IRF6 as an inhibitor of epithelial-mesenchymal transition.

Journal of biological engineering·2026
Same author

Early infection after aseptic revision shoulder arthroplasty: prevalence and predisposing risk factors.

JSES international·2026
Same author

Development of a STEAP1-Targeted Prostate Cancer Specific Antibody Drug Conjugate Platform with Immunostimulatory Properties.

Research square·2026

相关实验视频

Updated: Jun 10, 2025

A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells
12:48

A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells

Published on: February 16, 2018

7.4K

细胞周期阶段进展分析确定了软组织肉瘤中三个独特的表型.

Mark M Cullen1, Alexander L Lazarides2, Patricia D Pittman3

  • 1Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA. mark.cullen@duke.edu.

BMC cancer
|October 16, 2024
PubMed
概括

三种肉瘤细胞周期表型显示出预后意义,类似于AJCC分期系统. 现型III瘤显著降低了存活率,这表明它们在软组织肉瘤中的预后价值.

关键词:
细胞周期的细胞周期.现象类型 现象类型预测 预测 预测 预测肉瘤肉瘤是一种肉瘤.

更多相关视频

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

6.9K
Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids
10:44

Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids

Published on: December 28, 2015

13.0K

相关实验视频

Last Updated: Jun 10, 2025

A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells
12:48

A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells

Published on: February 16, 2018

7.4K
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

6.9K
Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids
10:44

Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids

Published on: December 28, 2015

13.0K

科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 癌症研究 癌症研究

背景情况:

  • 细胞周期标志物和表型在乳腺癌中确立了预后意义.
  • 了解肉瘤中的这些标记物对于改善患者的治疗结果至关重要.

研究的目的:

  • 在肉瘤中识别预后细胞周期标记物.
  • 评估在肉瘤中特定细胞周期表型的预后潜力.

主要方法:

  • 分析了来自128种主要软组织肉瘤的组织样本.
  • 四种细胞周期标记物 (Mcm2,Gemini,Plk1,H3S10ph) 用于染色.
  • 导出了三个细胞周期表型,并使用Cox回归评估了它们的预后意义.

主要成果:

  • 与I型相比,Phenotype III瘤的5年整体存活率,无病存活率和无转移存活率显著下降.
  • 高表达的Plk1和双子素与总生存率的降低有关.
  • 鉴定的表型显示出与AJCC分期系统相比较的预后性能.

结论:

  • 鉴定出了三种具有显著预后价值的 Sarcoma 细胞周期表型.
  • 这些表型为预测肉瘤患者的结果提供了有价值的工具.
  • 这些发现表明,细胞循环分析可以补充肉瘤中现有的分期系统.