对EGFR突变NSCLC的最佳第一线治疗:对 osimertinib和第二代EGFR-TKI进行比较分析
Hsu-Yuan Chen1,2, Chia-Hung Chen1,2, Wei-Chih Liao1,2
1Department of Internal Medicine, Division of Pulmonary and Critical Care, China Medical University Hospital, Taichung, Taiwan.
奥西默提尼布和第二代EGFR-TKIs在EGFR突变的高级非小细胞肺癌 (NSCLC) 中表现出类似的有效性. 在一线治疗中,NSCLC阶段是无进展生存的关键预测因素.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 奥西默提尼布是EGFR突变非小细胞肺癌 (NSCLC) 的首选一线治疗方法.
- 仅有有限的数据可以比较 osimertinib 与第二代 (2G) EGFR-TKIs 在一线设置中.
- 这项研究通过比较临床结果来弥补这一差距.
研究的目的:
- 为了比较 osimertinib 与第二G EGFR-TKIs (afatinib 和 dacomitinib) 的临床疗效,作为一线治疗.
- 在EGFR突变NSCLC患者中确定无进展生存 (PFS) 的预测因子.
主要方法:
- 对168名患有EGFR突变NSCLC的IIIb-IV期患者进行了回顾性研究.
- 患者接受了2nd G EGFR-TKIs或osimertinib作为第一线治疗.
- 分析了无进展生存期 (PFS) 和治疗失败的时间.
主要成果:
- 在 osimertinib 和 2nd G EGFR-TKIs (17.6-20.0 个月与 28.3 个月) 之间,PFS 中位数没有显著差异.
- 奥西默提尼布在EGFR外基因19缺失患者中显示了更长的PFS趋势,但在统计学上并不显著.
- NSCLC阶段是PFS唯一独立的负面预测因素;二线治疗模式有显著差异.
结论:
- 奥西默提尼布和第2GEGFR-TKIs的疗效与EGFR突变的晚期NSCLC的第一线治疗相似.
- NSCLC阶段是影响PFS的关键因素.
- 需要进一步的研究来评估不同二线治疗对整体存活时间的影响.
更多相关视频
09:38Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib
Published on: June 26, 2019
09:38Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
Published on: August 11, 2017
相关概念视频
Targeted Cancer Therapies
There are several types of targeted therapies against...
Mitogens and the Cell Cycle
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
