在IVF/ICSI的对抗剂协议中,莱特醇联合治疗的影响:一项回顾性研究
Jing Lin1, Fenglu Wu2, Bian Wang2
1Center for Reproductive Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Reproductive biology and endocrinology : RB&E
|October 16, 2024
概括
在体外受精 (IVF) 中,添加莱特醇到对抗剂协议的结果是类似的活产率. 这种组合疗法还降低了妊娠糖尿病的风险,并为妊娠年龄的婴儿提供了一个小的婴儿.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 反对者协议是IVF受控卵巢刺激的标准.
- 莱特醇有时被作为辅助剂使用,但其对活产率和安全性的影响需要进一步调查.
研究的目的:
- 评估莱特醇与抗剂结合方案对试管婴儿活产率的影响.
- 评估与这种联合治疗相关的孕产妇和新生儿并发症风险.
主要方法:
- 对4780名接受试管婴儿/ICSI,新鲜胚胎移植的妇女进行了回顾性队列研究.
- 单独使用对抗剂协议和与莱特醇联合治疗的对抗剂协议之间的结果比较.
- 使用后勤回归,倾向得分匹配 (PSM) 和反向概率加权 (IPW) 进行分析.
主要成果:
- 莱特醇联合治疗的活产率与单独使用抗剂的治疗方案相比相当.
- 在BMI≥24和高卵巢响应的女性中,观察到与莱特醇联合治疗的活产率更高.
- 莱特醇的联合治疗与妊娠糖尿病的风险降低以及为妊娠年龄的婴儿分娩的风险降低有关.
结论:
- 在试管婴儿的对抗剂协议中,莱特醇的联合治疗产生了与新鲜胚胎移植相比较的活产率.
- 组合治疗似乎是安全的,有可能减少特定的孕产妇和新生儿并发症.
- 建议进行前性随机试验以证实这些发现.
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