增加的甲状腺激素敏感性与2型糖尿病患者内脏肥胖相关
Lu Yu1,2, Yujia Liu1, Yingxuan Wang1
1Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China.
Lipids in health and disease
|October 16, 2024
概括
甲状腺激素 (TH) 敏感性与2型糖尿病 (T2D) 患者的内脏肥胖有关. 更高的敏感性与内脏脂肪增加相关,特别是在年轻,非肥胖的人群中.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 糖尿病研究 糖尿病研究
背景情况:
- 2型糖尿病 (T2D) 通常与代谢并发症有关,包括内脏肥胖.
- 甲状腺激素 (TH) 在调节新陈代谢方面发挥着至关重要的作用.
- 了解TH敏感度和T2D内脏脂肪之间的关系对于管理代谢健康至关重要.
研究的目的:
- 为了研究甲状腺激素 (TH) 敏感性和T2D无甲状腺患者内脏脂肪区域 (VFA) 之间的关联.
- 为了确定内脏肥胖是否与这种患者群体中改变的TH敏感性有关.
主要方法:
- 招募了750名患有T2D的euthyroid患者.
- 定义的内脏肥胖症是内脏脂肪面积 (VFA) ≥80厘米2.
- 使用TT4RI,TSHI和TFQI评估中央TH敏感性,使用FT3/FT4比率评估外围TH敏感性.
主要成果:
- 在多变量分析中,更高的FT3/FT4比率 (表明更大的外围TH敏感性) 与内脏肥胖有积极的相关性 (P <0.05).
- 中等和最高FT3 / FT4第三层的个体与最低第三层相比,内脏肥胖的患病率明显更高.
- 提升的TFQI水平 (表明更大的中央TH敏感性) 与内脏肥胖的流行率降低有关.
结论:
- 增加的甲状腺激素 (TH) 敏感性与T2D euthyroid患者的内脏肥胖和更高的内脏脂肪区域 (VFA) 有关.
- 这种联系在60岁以下的个人和那些没有超重或肥胖的人中更为明显.
- 研究结果表明,TH调节与T2D中的脂肪分布之间存在潜在的联系.
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