相关实验视频
Updated: Jun 10, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
抗生素暴露作为IBD流行病风险因素的作用:更新的元分析
Rui Pan1, Yang He1, Jiami Yuan1
1School of Public Health, Health Science Center, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang, 315211, China.
抗生素暴露与患炎症性肠病 (IBD) 的风险增加有关. 限制不必要的抗生素使用可能有助于减少全球IBD的发病率.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 全球炎症性肠病 (IBD) 发病率上升.
- 人们越来越担心抗生素暴露对IBD发展的潜在影响.
研究的目的:
- 对抗生素暴露与IBD风险之间的关联进行元分析.
- 检查诸如暴露时间,频率和区域差异等因素.
主要方法:
- 对多个数据库 (PubMed,科学网等) 的综合文献综述. 在2024年6月之前.
- 包括18个病例控制和5个队列研究.
- 基于抗生素暴露时间,频率和地理区域的分层分析;用于元分析的随机效应模型.
主要成果:
- 抗生素暴露与IBD风险之间存在显著的正相关性 (OR, 1.66).
- 较长时间 (≥3年,2年) 和较高频率 (≥3,2次) 的抗生素使用观察到风险增加.
- 在发达国家发现了显著的关联,但在发展中国家没有.
结论:
- 抗生素使用与患IBD的风险增加有关.
- 减少不必要的抗生素处方可能是缓解IBD发病率的策略.
更多相关视频
08:24Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
06:57Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
相关概念视频
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Antibiotic Selection