对糖尿病病中表达的新生物标志物的洞察:潜在的临床应用
Shalu Chauhan1, Uma Bhandari1, Anwar Habib2
1Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India.
Current pharmaceutical design
|October 17, 2024
概括
早期发现糖尿病病 (DN) 是至关重要的. 本综述探讨了包括miRNA和蛋白质组在内的当前和未来的生物标志物,以改善诊断和预防病进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 糖尿病病 (DN) 是一个日益严重的全球健康问题,与2型糖尿病 (DM) 的增加并行.
- 早期诊断DN对于管理DM及其并发症的重大社会和经济负担至关重要.
- 传统标记物微专尿 (MA) 在检测早期损伤方面存在局限性,特别是非专尿性DN.
研究的目的:
- 综合审查现有和新兴的生物标志物,用于糖尿病病的早期诊断和预测.
- 评估早期慢性病 (CKD) 检测的诊断方法,包括球体和管状损伤标志物.
- 探索新的未来生物标志物,包括奥米克和肠道微生物群,以增强DN检测.
主要方法:
- 对糖尿病病诊断生物标志物的当前文献进行系统审查.
- 生物标志物的分类为已建立的 (球体,管状,氧化应激,炎症) 和新兴的 (miRNA,蛋白质组,代谢组,基因组,肠道微生物群).
- 分析这些生物标志物在识别早期脏异常和结构性损伤方面的潜力.
主要成果:
- 微专尿 (MA) 是早期DN检测的不足标志物,特别是在非专尿形式.
- 淋巴细胞和管状细胞损伤,氧化应激和炎症的各种标志物显示出早期DNA识别的前景.
- 未来的生物标志物,如miRNAs,蛋白质组学,代谢组学,基因组学和肠道微生物群,为更精确和更早的诊断提供了潜力.
结论:
- 确定可靠和特定的生物标志物对于改善DN的临床管理和患者生活质量至关重要.
- 新兴的血清和尿路生物标志物对早期DN诊断具有前景,可能降低患病率并防止进展至末期病 (ESRD).
- 欧米茄技术和肠道微生物群分析的进步为更早,更准确的DN检测提供了显著的前景.
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