记忆形成和回忆之间的时间顺序的保存的神经代码在人类中枢叶中
Mohammad Farhan Khazali1, Armin Brandt1, Peter C Reinacher2,3
1Epilepsy Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
bioRxiv : the preprint server for biology
|October 17, 2024
概括
人体中叶 (MTL) 神经元编码经历事件的时间顺序. 这种神经代码在记忆形成和回忆过程中被保存,帮助时间记忆.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 记忆研究 记忆研究
背景情况:
- 时间记忆,即记住事件的顺序的能力,对于生活经验至关重要.
- 中间叶 (MTL) 参与时间记忆,但其细胞机制尚不清楚.
研究的目的:
- 调查人类MTL神经元活动是否代表记忆编码和回忆期间的时间位置.
- 识别在记忆中的时间顺序保存背后的细胞机制.
主要方法:
- 来自19名人类患者的侵入性单单和多单元记录.
- 在虚拟环境中,分析神经元发射率与对象呈现顺序的关系.
- 在记忆编码和回忆任务期间检查神经活动.
主要成果:
- 在对象探索过程中,在MTL神经元 (包括海马体) 中观察到显著的时间位置选择性.
- 在回忆过程中神经元的激发速度显示出选择性,支持检索时间顺序.
- 大多数神经元在编码过程中选择性,在回忆过程中保持它们的时间偏好.
结论:
- 人类MTL神经活动包含了一个保存的神经代码,用于时间顺序.
- 这个代码在记忆形成和回忆过程中都存在.
- 这表明人类大脑中时间记忆的基本机制.
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