神经关联的巨细胞在整个生命周期中控制脂肪平衡,并抑制与年龄相关的炎症
bioRxiv : the preprint server for biology
|October 17, 2024
概括
老化脂肪组织巨细胞 (ATM) 发生变化,血管相关巨细胞 (VAM) 减少,脂质相关巨细胞 (LAM) 扩大. 专门的神经相关巨细胞 (NAMs) 衰退,增加炎症和损害脂肪代谢.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 衰老研究研究 衰老研究
背景情况:
- 与年龄相关的炎症或炎症是疾病和死亡率的重要驱动因素.
- 脂肪组织巨细胞 (ATM) 在炎症中的作用由于对利基特定的ATM身份的不完全了解,人们对其了解甚少.
- 脂肪组织恒温及其与衰老的联系需要进一步研究.
研究的目的:
- 在内脏白脂肪组织 (VAT) 中定义位居民ATM的多样性和与寿命相关的变化.
- 阐明特定的ATM子集在调节脂肪组织炎症和衰老过程中的代谢中的功能作用.
主要方法:
- 血管内标记以隔离居民ATM与循环的髓状细胞.
- 单细胞测序和直角验证以识别ATM子集.
- 对老年小鼠和年轻小鼠的ATM种群的分析.
主要成果:
- 衰老导致了血管相关巨细胞 (VAMs) 的枯竭,并在VAT中增加了脂质相关巨细胞 (LAMs).
- 一个新的子集,CD38+年龄相关巨细胞 (AAMs),随着年龄的增长而出现.
- 神经相关巨细胞 (NAMs),特别是CD169+CD11c-,随着年龄的增长而下降.
- 在老年小鼠中,CD169+ NAMs的耗尽加剧了炎症和脂质分解的损伤,表明了catecholamine耐药性.
结论:
- 专门的ATM子集在维持脂肪组织平衡中起着至关重要的作用.
- 与ATM的年龄相关的变化,特别是NAM的下降,导致增值税的炎症和代谢功能障碍.
- 这些发现强调了特定的ATM种群,炎症和衰老期间组织功能障碍之间的直接联系.
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