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Updated: Jun 10, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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在人类IGF-1基因中识别功能罕见的编码变异,具有异常长寿

Amanat Ali1,2, Zhengdong Zhang3,2, Tina Gao1,2

  • 1Department of Medicine, Albert Einstein College of Medicine, NY, USA, 10461.

bioRxiv : the preprint server for biology
|October 17, 2024
PubMed
概括

在百岁以上的人群中发现了胰岛素样生长因子-1 (IGF-1) 基因的两种新型遗传变异. 这些变体,IGF-1:p.Ile91Leu和IGF-1:p.Ala118Thr,通过减少IGF-1信号传递,可能有助于人类的长寿.

关键词:
在IGF-1的基础上,IGF-1在IGF-1RR中,IGF-1R是最常见的.老化的老化 衰老的老化遗传变异是一种遗传变异.分子动力学分子动力学

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