腹腔带与突出网络具有优先相关性,包括背侧前额叶皮层的区域
bioRxiv : the preprint server for biology
|October 17, 2024
概括
腹状条纹体 (VS) 连接到 Salience 网络,包括背侧前额皮层 (DLPFC). 这一发现表明DLPFC可能是一个个性化的神经调节标,用于治疗严重抑郁症.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 功能神经成像 功能神经成像
背景情况:
- 腹状条纹体 (VS) 对于奖励和动机处理至关重要,它从皮质接收输入,并由中脑多巴胺调节.
- 了解与VS相关的皮质组织对于阐明奖励和动机中的大脑功能至关重要.
研究的目的:
- 探索与人类VS连接的皮质区域的组织.
- 使用功能性MRI (fMRI) 调查VS和皮质网络之间的功能连接.
主要方法:
- 在密集扫描参与者的个人功能连接内利用MRI.
- 在VS中定义了种子区域,并分析了与分布的皮质区域的相关性.
- 在独立的数据集中复制发现,并将其推广到更大的队列中.
主要成果:
- VS种子区域与属于 Salience (SAL) 网络的皮质区域显示出优先相关性.
- 这种SAL网络地形包括前/后中间线区域,前岛和背侧前额皮层 (DLPFC).
- 确定的DLPFC区域与参与认知控制的区域相邻,并且在所有参与者中始终与VS相结合.
结论:
- 该VS形成一个皮质-基底结环,集成在SAL网络中.
- DLPFC与VS的一致合表明它有可能成为主要抑郁障碍的神经调节标.
- 这些发现支持针对DLPFC的个性化神经调节策略,基于其与VS的连接性.
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