自杀死亡前一年药物使用模式:澳大利亚基于人口的案例系列研究研究
Andrea L Schaffer1,2, Nicholas A Buckley3,4, Jennifer Schumann5,6
1Medicines Intelligence Research Program, School of Population Health, UNSW Sydney, Sydney, Australia.
EClinicalMedicine
|October 17, 2024
概括
在自杀前的一年里,抗抑郁药和二氨酸药的开放量显著增加,不论其方法如何. 这可能表明精神健康症状恶化或死亡前寻求帮助的行为增加.
科学领域:
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
- 临床毒理学 临床毒理学
背景情况:
- 心理健康药物对于治疗至关重要,但也经常涉及到因中毒而导致的自杀死亡.
- 这项研究检查了自杀死亡前一年的抗抑郁药,二类药和抗精神病药的发行模式.
研究的目的:
- 量化自杀前一年的主要精神病药物发行和开始使用的变化.
- 分析这些变化与自杀方法 (药物中毒与其他原因) 相比.
主要方法:
- 一个描述性的,基于人口的案例系列研究,使用澳大利亚国家数据 (冠状和分发索赔) 从2013-2019年.
- 包括因自杀而死亡的10岁及以上的个人.
- 分析了按死亡原因分层的每周药物分发的总量,使用零碎线性回归.
主要成果:
- 在那些因药物中毒而死亡的人群中,与其他原因相比,神经系统药物使用率更高.
- 不管死因如何,服用二类药物在离死亡时间更近的时间显著增加.
- 除了药物中毒之外,那些因自杀而死亡的人中,抗抑郁药物处方也增加了更接近死亡的可能性.
结论:
- 离死亡日期更近的抗抑郁药和二胺类药物的开放增加表明症状可能恶化或寻求帮助的增加.
- 自杀的方法可能会受到这些药物更容易获得的影响.
- 研究结果强调,需要仔细监测那些有自杀风险的人的药物使用情况.
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