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表面扩散系数在诊断直肠癌中的重要性

Milica Šarošković¹, Miloš Vuković^1,2, Stefan Stojanoski^1,2

¹Department of Radiology, Faculty of Medicine Novi Sad, University of Novi Sad, Novi Sad, Serbia.

Frontiers in oncology

|October 17, 2024

概括

显微扩散系数 (ADC) 磁力共振成像有效地区分直肠癌与辐射后直肠炎和正常直肠组织. 然而,ADC值与瘤等级或其他病理特征无关.

科学领域:

放射学放射学是一门学科.
在瘤学瘤学.
医疗成像医学成像

背景情况:

表面扩散系数 (ADC) 是一个定量MRI参数.
准确区分直肠病理对于有效治疗至关重要.
区分直肠癌与辐射后直肠炎和正常直肠壁的区别可能是具有挑战性的.

研究的目的:

评估ADC值在区分直肠癌与放射后直肠炎和正常直肠壁的有用性.
为了在这三个条件中比较ADC值.
评估ADC值与瘤标志物和组织病理学特征的相关性.

主要方法:

一项回顾性研究包括300名患者:100名直肠癌患者,100名放射后直肠炎患者,100名直肠正常患者.
从直肠壁使用感兴趣区域 (ROI) 方法测量了平均ADC值.
进行了统计分析,以比较ADC值并评估相关性.

主要成果:

结直肠癌的ADC值显著较低 (0.665 ± 0.086 x 10^-3mm²/s),与放射后结直肠炎 (1.648 ± 0.268 x 10^-3mm²/s) 和正常结直肠 (1.180 ± 0.110 x 10^-3mm²/s) (p<0.001) 相比.
低于1.013 x 10^-3mm²/s的ADC值显示了100%的灵敏度和96%的特异性,用于检测直肠癌与正常壁的癌症.
在ADC值和直肠癌等级,淋巴结转移,TN阶段,瘤扩散,RAS突变或瘤标志物之间没有发现显著的相关性.

结论:

ADC测量在区分直肠癌与辐射后直肠炎和正常直肠组织方面非常有效.
ADC值显示高灵敏度和特异性用于识别直肠癌.
ADC分析不适合区分直肠癌的组织学等级或其他病理学参数.

关键词:

这是一个ADCADC ADC.酒后驾驶酒后驾驶酒后驾驶 TNM TNM 在线观看淋巴结中的淋巴结.辐射后的直肠炎这是直肠癌.

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