在阿尔茨海默病和主观认知障碍中,冷漠和基于努力的决策
Bahaaeddin Attaallah1,2, Sofia Toniolo1, Maria Raquel Maio1
1Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK.
Alzheimer's & dementia (Amsterdam, Netherlands)
|October 17, 2024
概括
在阿尔茨海默病 (AD) 和主观认知障碍 (SCI) 中的冷漠机制使用基于努力的决策 (EBDM) 框架进行了探索. 结果显示,在AD和SCI中,类似的决策中断,分别与执行功能和冷漠有关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 精神病学是一个精神病学.
背景情况:
- 漠不关心是阿尔茨海默病 (AD) 和主观认知障碍 (SCI) 的关键症状.
- 在这些条件下,人们对冷漠的潜在机制仍然不太了解.
- 这项研究开创了基于努力的决策 (EBDM) 框架的使用,以调查AD和SCI中的冷漠.
研究的目的:
- 通过基于努力的决策 (EBDM) 框架,研究阿尔茨海默病 (AD) 和主观认知障碍 (SCI) 中的冷漠机制.
- 为了比较AD患者,SCI参与者和健康对照 (HC) 之间的冷漠程度和决策过程.
- 探讨AD和SCI中冷漠,执行功能障碍和神经连接之间的关系.
主要方法:
- 基于努力的决策 (EBDM) 框架应用于30名AD患者,41名SCI参与者和55名健康对照 (HC).
- 用漂移扩散模型 (DDM) 分析数据,以确定潜在的心理过程.
- 评估了功能性皮质连接,特别是与核的连接.
主要成果:
- 自我报告的冷漠性在SCI参与者中高于AD患者和HC患者.
- 与自我报告和HC相比,informant报告显示AD患者的冷漠度较高.
- 无论是AD还是SCI组都表现出对努力的敏感性降低,这与AD中的执行功能障碍和SCI中的冷漠有关.
- 在SCI中,休息功能连接的增加与SCI中较高的冷漠度相关.
结论:
- 这项研究表明,在阿尔茨海默病 (AD) 和主观认知障碍 (SCI) 两种疾病中,基于努力的决策 (EBDM) 存在共同的干扰.
- 这种EBDM干扰与AD的执行功能障碍和SCI的冷漠不同.
- 研究结果表明,尽管有类似的行为结果,在这些条件下,不同的神经认知途径有助于冷漠.
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