德克斯梅德托米丁导致了手术后应激反应的改善
Khalida Ajmal1, Akbar Waheed2, Rashada Farooqi3
1Dr. Khalida Ajmal, MBBS, M.Phil., CHPE, Department of Pharmacology, Wah Medical College, Wah Cantt, Pakistan.
Pakistan journal of medical sciences
|October 17, 2024
概括
术后静脉注射的德克斯梅托米丁 (Dex) 显著降低了ENT手术患者的皮质醇和白内素等压力标志物. 这表明Dexmedetomidine是一种药物.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 术后应激反应涉及复杂的生理和免疫学变化.
- 炎症生物标志物,如皮质醇,TNF-α和互白蛋白-6是这种压力的关键指标.
- 了解可以调节这种反应的干预措施对于患者的康复至关重要.
研究的目的:
- 为了评估静脉注射德克斯梅托米丁 (Dex) 对外科手术期间应激反应标志物的影响.
- 评估Dexmedetomidine对在接受耳鼻腔外科手术的患者中皮质醇,TNF-α和插白蛋白-6的血清水平的影响.
主要方法:
- 一项随机干预性研究,涉及100名年龄在15-60岁的患者,接受耳,耳,耳,耳,耳,耳,耳,耳手术.
- 患者被分为两组:对照组 (正常盐水) 和干预组 (德克斯梅德托米丁).
- 德克斯梅德托米丁在诱导前和作为维持剂量被静脉注射. 血清生物标志物被测量在0,30分钟和2小时后使用ELISA.
主要成果:
- 接受德克斯梅德托米丁治疗的患者显示,皮质醇,TNF-α和IN-6的血清水平显著降低.
- 在德克斯梅托米丁组中,皮质醇水平从139.73降至10.18,TNF-α从99.51降至0.96,白内素-6从85.09降至0.96.
- 对于这些生物标志物,在对照组和德克斯梅德米丁组之间观察到具有统计学意义的差异 (p≤0.05).
结论:
- 静脉注射Dexmedetomidine有效地抑制了细胞因子分泌在手术期间的增加.
- 德克斯梅德托米丁的使用与患者恢复的改善以及恶心和吐的发生率的减少有关.
- 德克斯梅德托米丁的抗炎性质可能是这些观察到的有益作用的原因.
相关概念视频
01:24General Anesthesia: Overview
196
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
196
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
149
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
149
01:22Stages of General Anesthesia
379
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
379
01:31Skeletal Muscle Relaxants: Therapeutic Uses
470
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
470