相关实验视频

Updated: Jun 10, 2025

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

Published on: December 9, 2022

C1q的损失会改变听觉脑干反应

Sima M Chokr¹, Ashley Bui-Tran¹, Karina S Cramer¹

¹Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, United States.

Frontiers in cellular neuroscience

|October 17, 2024

概括

补充蛋白C1q在发育过程中存在于听觉脑干中. 在小鼠中C1q缺乏微妙地影响听觉脑干响应 (ABR) 峰值延迟,而不会影响听觉值或突触修剪.

科学领域:

神经科学是一个神经科学.
审计系统开发审计系统开发
突触性可塑性突触性可塑性

背景情况:

听觉大脑干中的神经回路,特别是腹腔耳核 (VCN) 和形状的中间核 (MNTB),对于声音定位至关重要.
微质在突触修剪中发挥作用,当微质被抑制时,修剪受损和听觉脑干反应 (ABRs) 证明了这一点.
由C1q启动的补充级联是已知的微质途径,参与突触修剪和可塑性.

研究的目的:

研究古典补充路径启动器C1q在听觉脑干成熟中的作用.
确定声音局部化途径中C1q的发育表达模式.
评估C1q删除对听觉脑干功能和突触发育的功能影响.

主要方法:

在小鼠的产后发育期间,研究了MNTB中的C1q表达.
分析了微质内和MNTB主要神经元周围的C1q定位.
评估了C1q删除对微质依赖的皮切割,突触标记物和C1q淘汰 (KO) 小鼠中的ABR的影响.

主要成果:

检测到C1q表达在MNTB的第一个产后周,随着年龄的增长.
在微质和周围的MNTB主要神经元中发现了C1q.
删除C1q并没有影响微质依赖的形切割或改变MNTB和LSO中的突触标志物. C1q KO小鼠表现出正常的听力值,但缩短了ABR峰值延迟时间.

结论:

这项研究确定了在听觉脑干的声音定位通路内C1q表达的发育时间表.
失去C1q会导致听觉处理中的微妙功能变化,特别是缩短ABR峰值延迟,而不会影响基本的听觉或突触修剪机制.
在听觉脑干成熟过程中,C1q扮演着微妙的角色,与以前观察到的微质细胞被广泛抑制时的效果不同.

关键词:

听觉大脑干听觉大脑干补充补充补充补充补充补充补充.梯形体的中间核 (MNTB)微质细胞中的微质细胞神经发育神经发育

更多相关视频

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

相关概念视频

Auditory Pathway

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...

The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

Hair Cells

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.