解读塑化剂和溶剂系统在性聚合物涂层中对性核心的作用
Deepak Khobragade1, Pramod Parshuramkar1, Surendra Agrawal1
1Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (DU), Wardha, Maharashtra, 442003, India.
Heliyon
|October 17, 2024
概括
这项研究发现,一种特定的溶剂混合物 (异醇-水 9:1) 和疏水性可塑剂是乙烯基纤维素-高纤维素聚合物涂层的最佳选择,改善了药物释放控制和薄膜特性.
科学领域:
- 制药技术 制药技术 制药技术
- 聚合物科学 聚合物科学
- 材料科学 材料科学 材料科学
背景情况:
- 乙纤维素 (EC) 和高纤维素 (HPMC) 是用于药物释放修饰的聚合物.
- 优化聚合物薄膜的性能,如透性和机械强度,对于控制药物输送至关重要.
- 塑化剂和溶剂对聚合物涂料的特性有很大的影响.
研究的目的:
- 确定以乙纤维素-高纤维素聚合物组合的最佳溶剂系统和可塑剂.
- 评估这些选择对涂层特性,薄膜特性和体外药物释放的影响.
- 评估固化时间对表面特性和药物释放行为的影响.
主要方法:
- 评估涂层溶液的性能和工艺效率.
- 分析物理平板电脑的属性和聚合物薄膜表面的特性.
- 在体外释放药物的研究和愈时间效应的评估.
主要成果:
- 一种异醇与水的混合物 (9:1) 产生了均的薄膜.
- 水友性增塑剂导致药物扩散率高于疏水性增塑剂.
- 疏水性可塑剂 (双脂酸盐,乙三酸盐) 并没有显著影响药物释放.
结论:
- 异醇-水 (9:1) 混合物是乙烯基纤维素-高纤维素涂层的优质溶剂.
- 疏水性增塑剂减少了与结合乙烯基纤维素和高纤维素相关的风险.
- 精心选择溶剂和增塑剂是调节药物释放和薄膜特性的关键.
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