COVID-19死亡率中的性别差异:一项大型美国队列研究 (2020-2022)
Samer A Kharroubi1,2, Marwa Diab-El-Harake1
1Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, P.O.BOX: 11-0236, Riad El Solh 1107-2020 Beirut, Lebanon.
AIMS public health
|October 17, 2024
概括
随着时间的推移,男性的COVID-19 (冠状病毒疾病2019) 死亡率更高. 了解性别特异性因素对于开发有针对性的治疗方法至关重要.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 根据时间和性别评估COVID-19 (冠状病毒疾病2019) 死亡率的趋势.
- 调查观察到基于性别的死亡率差异的潜在原因.
- 使用Datavant的死亡指数数据库进行大规模的队列分析.
研究的目的:
- 分析随时间推移的COVID-19死亡率趋势,按性别和年龄分层.
- 识别和理解导致COVID-19结果性别差异的因素.
- 为制定COVID-19的性别特异性治疗策略提供信息.
主要方法:
- 对美国和加拿大的4,384,265名已故人进行了回顾性队列研究.
- 包括2022年1月至12月COVID-19诊断的成年男性和女性患者 (ICD-10代码:U07.1)
- 在三年内对死亡病例的分析,计算性别比率并说明特定年龄组的死亡率.
主要成果:
- 尽管疫苗推出,但COVID-19死亡率在2021年达到顶峰,受到假日聚会和传染性菌株的影响.
- 在2022年,由于接种疫苗和自然免疫力,死亡率下降,但男性诊断增加.
- 在整个大流行期间,按性别的病例比例稳定,但男性死亡率更高.
结论:
- 男性的COVID-19死亡率较高与社会,行为和生物因素有关.
- 这些发现强调了对COVID-19的性别特定治疗和干预策略的需要.
- 按性别分类的数据分析对于理解和减轻与流行病相关的健康差异至关重要.
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