Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.8K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.8K
Hematopoiesis01:21

Hematopoiesis

5.1K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

1.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
1.3K
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

BEACH domain-containing proteins: emerging roles in hematopoiesis and immune homeostasis.

Current opinion in hematology·2026
Same author

Chemotherapy-driven expression of WNT ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia.

British journal of haematology·2026
Same author

Unbiased recording and identification of thymic cellular interactomes using synthetic Notch receptors.

Nature communications·2026
Same author

Hematopoietic stem cell-independent and -dependent hematopoiesis: new insights and lineage-tracing methods.

Experimental hematology·2025
Same author

Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar.

Experimental hematology·2025
Same author

The release of catecholamines to the cytosol and the exocytosis of secretory vesicles triggered by IP<sub>3</sub> in chromaffin cells.

American journal of physiology. Cell physiology·2025
Same journal

Mesenchymal stem cells-derived extracellular vesicles as a novel drug delivery carrier: engineering strategies and clinical safety estimation.

Frontiers in molecular biosciences·2026
Same journal

Preparation and analysis of tobacco glycosides, and the relationship between glycoside aglycones and pyrolysis products: a review.

Frontiers in molecular biosciences·2026
Same journal

Peritoneal metastasis in pancreatic cancer: molecular mechanisms, microenvironmental remodeling, and emerging intraperitoneal interventions.

Frontiers in molecular biosciences·2026
Same journal

Insights from LC-MS-based cerebrospinal fluid metabolomics in tuberculous meningitis.

Frontiers in molecular biosciences·2026
Same journal

Emerging roles of Notch signaling in the tumor microenvironment of digestive system cancers.

Frontiers in molecular biosciences·2026
Same journal

Adenosine metabolism as an endogenous protective mechanism in response to upstream ischemic injury.

Frontiers in molecular biosciences·2026
查看所有相关文章

相关实验视频

Updated: Jun 10, 2025

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

7.9K

在发育过程中,不断演变的造血.

Raúl Sánchez-Lanzas1, Amanda Jiménez-Pompa1, Miguel Ganuza1

  • 1Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.

Frontiers in molecular biosciences
|October 17, 2024
PubMed
概括
此摘要是机器生成的。

造血干细胞 (HSC) 从胚胎动脉迁移到胎儿器官,形成终身血液干细胞池. 了解这些发育是白血病研究和再生医学的关键.

关键词:
大动脉 - 淋巴体 - 半胞体骨髓 骨髓 骨髓 骨髓 骨髓发育性血液形成胎儿肝脏 胎儿肝脏是什么造血的利基,也就是造血的利基.造血干细胞 造血干细胞

更多相关视频

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.0K

相关实验视频

Last Updated: Jun 10, 2025

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

7.9K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.0K

科学领域:

  • 发展生物学 发展生物学
  • 血液学 血液学 血液学
  • 干细胞生物学 干细胞生物学

背景情况:

  • 哺乳动物造血干细胞 (HSC) 起源于胚胎动脉,并迁移到胎儿肝脏和骨髓.
  • 成年HSCs维持终身造血,但它们的发育是不太了解的.
  • 最近的研究揭示了胎儿和成年HSC的差异,受炎症,微生物群和激素的影响.

研究的目的:

  • 审查目前对整个本体遗传学中HSC的知识.
  • 为了突出胎儿肝脏,胎儿骨髓和成人骨髓之间的差异.
  • 强调这些微环境对于理解高血压细胞发育和疾病的重要性.

主要方法:

  • 文献综述侧重于小鼠模型,与其他脊椎动物 (鸟类,斑马鱼,人类) 的比较见解.
  • 综合了最近关于HSC利基结构和功能的研究结果.
  • 对影响高学历的环境和发展因素的分析.

主要成果:

  • 在胎儿肝脏,胎儿骨髓和成人骨髓中存在显著差异.
  • 炎症,微生物群和荷尔蒙因素在调节HSC及其位方面发挥着至关重要的作用.
  • 支持HSC成熟和扩张的细胞组件在不同发育阶段有所不同.

结论:

  • 对HSC本体和的全面理解对于解决儿童白血病起源至关重要.
  • 了解HSC的发展对于推进再生医学至关重要,包括用于移植的HSC体外生产.
  • 本综述巩固了对HSC微环境的理解,以告知未来的治疗策略.