肠道微生物群和下肢深静脉血栓症与肺栓塞结合的因果关系
Qiyang Xu1, Jihong Fang2, Yi Wang3
1Department of General Surgery, Ningbo No.2 Hospital, Ningbo, China.
Frontiers in microbiology
|October 17, 2024
概括
肠道微生物群影响下肢深静脉血栓塞 (LEDVT) 和肺栓塞 (PE). 像Butyricicoccus这样的特定细菌可能会降低风险,而Clostridium innocuum可能会增加风险,这表明有因果关系.
科学领域:
- 微生物组研究的研究.
- 遗传学 是一个遗传学.
- 血管疾病流行病学
背景情况:
- 肠道微生物群的组成越来越多地与各种健康结果有关.
- 以前的研究表明,肠道细菌和静脉血栓塞栓症 (VTE) 之间存在联系.
- 肠道微生物群和下肢深静脉血栓塞 (LEDVT) 和肺栓塞 (PE) 之间的因果关系需要进行严格的调查.
研究的目的:
- 使用孟德尔随机化 (MR) 调查肠道微生物群在LEDVT和PE中的因果作用.
- 确定与LEDVT和PE风险相关的特定肠道微生物种群.
主要方法:
- 利用了来自肠道微生物群的MiBioGen联盟的全基因组关联研究 (GWAS) 总结数据.
- 采用了来自IEU Open GWAS项目的LEDVT和LEDVT与PE组合的总结级数据.
- 作为主要方法,使用逆方差加权 (IVW) 进行MR分析,并补充其他MR技术和灵敏度分析.
主要成果:
- 确定了肠道微生物群遗传责任和LEDVT之间的七种因果关系.
- 在肠道微生物群遗传责任和LEDVT与PE结合之间发现了五种因果关系.
- 发现*Butyricicoccus*属与降低风险有关,而*Clostridium innocuum*与这两种疾病的风险增加有关.
结论:
- 肠道微生物群与LEDVT和PE有因果关系.
- 调查结果提供了对VTE发展背后的机制的见解.
- 建议未来临床研究和干预LEDVT和PE的潜在目标.
相关概念视频
01:30Venous Thrombosis I: Introduction
3
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
3
01:29Pulmonary Embolism I: Introduction
2
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
2
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
3
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
3
01:29Venous Thrombosis III: Interprofessional Care
3
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
3
01:15Veins of Lower Limbs
671
The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the...
Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the...
671
01:27Pulmonary Embolism III: Nursing Management
6
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
6