通过血管变形测绘评估的生长率预测了马尔凡综合征的B型大动脉剖析
Carlos Alberto Campello Jorge1, Prabhvir Singh Marway1, Nicasius S Tjahjadi2
1Department of Radiology, University of Michigan, Ann Arbor, Michigan.
medRxiv : the preprint server for health sciences
|October 17, 2024
概括
大动脉生长和延长率,而不仅仅是直径,预测了马凡综合征 (MFS) 患者的B型大动脉剖析 (TBAD). 血管变形映射 (VDM) 识别了这些关键的TBAD风险因素.
科学领域:
- 心血管成像 - 心血管成像
- 医学诊断 医学诊断 医学诊断
- 遗传学和罕见疾病
背景情况:
- 马凡综合征 (MFS) 患者面临B型大动脉剖析 (TBAD) 的高风险.
- 大动脉的生长和延长被怀疑是TBAD的危险因素.
- 血管变形映射 (VDM) 分析了计算机断层扫描 (CTA) 扫描的3D大动脉生长.
研究的目的:
- 评估大动脉增长速度在下降胸前大动脉 (DescAo) 中的作用,使用VDM.
- 为了确定与MFS患者TBAD风险相关的因素.
- 为了比较TBAD风险分层的绝对大动脉直径的增长率.
主要方法:
- 使用VDM对105名成人MFS患者 (2004-2023) 的CTA扫描进行分析.
- 测量胸腔腹腔大动脉直径和DECAO长度.
- 在5.3年的中位数中对患者进行TBAD发展的监测.
主要成果:
- 在监测期间,12名 (11.4%) MFS 患者患有TBAD.
- 结核病患者的辐射生长率显著增加 (0.63比0.23毫米/年) 和延长率显著增加 (2.4比0.5毫米/年).
- 切割前的大动脉直径不是一个显著的预测因素,TBAD发生在非动脉瘤大小 (<4.0厘米) 的情况下.
结论:
- 下降胸前动脉 (DescAo) 径向生长和延长率是MFS中TBAD的独立预测因素.
- 对于MFS的TBAD风险分层,大动脉生长动态比绝对直径更为重要.
- 在MFS中,VDM是评估大动脉生长和TBAD风险的宝贵工具.
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