在精神分裂症中,受损的说话诱导的抑制预测了下降的代理和幻觉严重性的预测
Songyuan Tan1, Yingxin Jia1, Miriam Mathew1
1Department of Psychiatry, University of California, San Francisco, CA.
medRxiv : the preprint server for health sciences
|October 17, 2024
概括
精神分裂症患者表现出受损的代理,影响现实和语音监控. 发言诱导抑制的缺陷与幻觉严重程度的增加相关,这表明代理,听觉处理和精神病之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 精神病学是一个精神病学.
背景情况:
- 机关,即产生行动和思想的感觉,在精神分裂症 (SZ) 中受损,导致现实监测缺陷和精神病症状.
- 代理对于语音监控至关重要;干扰可以导致幻觉,因为错误地将内在语音归因为外部声音.
研究的目的:
- 通过磁脑图 (MEG) 在现实监测 (RM) 和语音监测 (SM) 任务中调查精神分裂症 (SZ) 中的代理缺陷.
- 探索受损发言诱导抑制 (SIS) 和幻觉严重程度在SZ之间的关系.
主要方法:
- 磁脑电图 (MEG) 用于在RM和SM任务期间测量健康对照组 (HC) 和SZ患者 (N=30每个) 的神经反应.
- 发言诱导抑制 (SIS),一个减少的M100听觉皮质响应在说话时,被评估在M100响应 (100ms后发言发作).
主要成果:
- 与HC相比,SZ患者在RM期间表现出自我和外部代理机构受损.
- 在SM期间,SZ患者未能表现出正常的听觉皮质抑制,这表明SIS受损,与幻觉严重程度的增加相关.
结论:
- 在听觉处理过程中,SZ中降低的神经M100反应导致SIS受损,增加了错误将内在语言归因为外部的可能性.
- 这种错误的归因导致现实监测中的代理干扰,并加剧精神分裂症中的幻觉.
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