孤独,表观遗传衰老和多病症之间的关联通过老年成人
Colin D Freilich1, Kristian E Markon1, Frank D Mann2
1Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
概括
孤独可能通过DNA甲基化加速生物衰老,导致老年人的慢性健康状况. 这种由GrimAge测量的表观遗传衰老过程,部分解释了社会隔离与多病症之间的联系.
科学领域:
- 老年学是指老年学的学科.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 公共卫生 公共卫生
背景情况:
- 孤独是一个重要的公共卫生问题,与身体健康状况不佳有关.
- 连接孤独与健康状况下降的精确生物机制仍然不清楚.
- 表观遗传途径,特别是DNA甲基化,正在成为潜在的调解者.
研究的目的:
- 调查孤独与表观遗传衰老加速 (EAA) 之间的关联.
- 确定EAA是否调解或缓解老年人孤独和慢性身体健康状况 (多病症) 之间的关系.
主要方法:
- 利用了来自健康和退休研究 (n=4,018) 的数据,并采用了血液采集用于甲基化概况.
- 基线孤独与EAA之间的估计关联使用GrimAge测量.
- 评估EAA对孤独与多种疾病联系的调解和适度效应.
主要成果:
- 在对共变量进行调整后,更高的基线孤独与更高的EAA (GrimAge) 有显著的关联 (β=0.07,p=0.003).
- 孤独和GrimAge都预测了慢性疾病数量的增加.
- GrimAge显著调解了孤独和多病症之间的关联 (间接路径β=0.020,p=0.003).
结论:
- 表观遗传加速衰老,特别是通过DNA甲基化,可能部分解释孤独如何影响身体健康并导致多病症.
- 像GrimAge这样的措施为了解孤独的生理后果提供了一个有希望的途径.
- 需要进一步的研究来阐明具体的生理途径.
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