人类免疫缺陷病毒对肺功能和结构的影响:系统性审查和元分析
Ioannis Konstantinidis1,2, Richard H Zou1, Spyridon N Papageorgiou3
1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Annals of the American Thoracic Society
|October 17, 2024
概括
人类免疫缺陷病毒 (HIV) 增加了阻塞性肺病 (OLD) 和肺气的风险. 对于携带艾滋病毒和呼吸系统症状的人来说,建议定期进行肺功能检测.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 阻塞性肺病 (OLD) 有吸入性和非吸入性原因.
- 人类免疫缺陷病毒 (HIV) 是一种潜在的新型OLD风险因素.
- 新出现的数据强调了艾滋病毒对肺功能的影响,特别是在低收入至中等收入国家.
研究的目的:
- 确定艾滋病毒感染与OldD之间的关联.
- 评估艾滋病毒和气体交换受损之间的联系.
- 评估艾滋病毒和肺瘤之间的关系.
主要方法:
- 对受控和观察性研究进行系统审查和元分析.
- 在多个数据库 (PubMed,Embase等) 进行了搜索. 通过2023年4月.
- 分析了OLD (精神测量),气体交换 (扩散能力) 和肺气 (CT扫描) 的数据.
主要成果:
- 艾滋病毒与OLD (OR,1.29) 和肺气 (OR,1.46) 的风险增加有关.
- 观察到气体交换受损的趋势 (OR, 2.63).
- 艾滋病毒阳性个体经历了更快的肺功能下降;艾滋病毒感染非洲人的风险最高.
结论:
- 艾滋病毒感染者面临更高的OLD风险,气体交换受损和肺气.
- 在艾滋病毒阳性个体中,OLD风险存在区域差异.
- 建议对有症状的艾滋病毒阳性个体进行螺旋测量和扩散能力测试.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:29Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K