在年轻和年长的成年人中,高温症期间的胃肠道透性和损伤风险
Zachary J McKenna1,2, Whitley C Atkins1,2,3, Taysom Wallace1
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Experimental physiology
|October 17, 2024
概括
在热应激期间,老年人可能会经历更大的胃肠透性,其证据是糖分泌量增加. 然而,热引起的损伤和炎症反应在年轻人和老年人之间是相似的.
科学领域:
- 身体生理学 身体生理学
- 老年学是一门学科.
- 环境健康 环境健康
背景情况:
- 热应激带来了生理上的挑战,特别是关于胃肠道和功能.
- 老龄化可能会改变对环境压力的生理反应,例如热量.
- 了解热应激反应的年龄相关差异对于公共健康至关重要.
研究的目的:
- 为了比较年轻和老年人之间的胃肠道透性和损伤标记在受控热应激下.
- 调查热应激对肠道屏障完整性和各个年龄段的炎症标志物的影响.
- 为了确定年龄是否调节对热引起的压力的反应.
主要方法:
- 在年轻人和老年人中使用透水的西装诱导受控高温,将核心温度提高2°C.
- 通过多糖 (乳糖,糖糖,糖) 饮料测试来评估胃肠道的透性.
- 血液和尿液样本被分析为肠道损伤 (I-FABP,LBP,sCD14),炎症,功能 (肌素,囊素C) 和损伤 (TIMP-2 × IGFBP7,NGAL,KIM-1) 的标志物.
主要成果:
- 这两个年龄组都显示了胃肠道透性增加,由较高的乳糖与拉姆诺斯比率表明.
- 年长的成年人表现出糖分泌量显著增加,这表明潜在的胃肠透性变化.
- 热应激导致青少年和老年人血LBP,肌素,囊素C和尿TIMP-2 × IGFBP7的比较增加,其他测量的肠道或损伤标志物没有显著差异.
结论:
- 控制的热应激会在年轻人和老年人中诱导轻微的胃肠道透性和炎症反应.
- 老年人可能更容易受到加热暴露期间胃肠透率的增加.
- 热应激会损害功能,并在不同年龄组中同样提高损伤标志物,这表明年龄不会调节这些特定反应.
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