有氧运动通过调节大脑内源性阿片类质来预防和改善因吗啡戒断引起的认知功能障碍
Shanghua Dai1,2,3, Yigang Dong2,3, Haifeng Shi2,3
1Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Psychopharmacology
|October 17, 2024
概括
有氧运动通过调节dynorphins来预防和改善吗啡戒断导致的认知缺陷. 运动降低了海马体中的丁诺芬前体 (PDYN) 和mPFC中的卡帕阿片类受体1 (OPRK1),恢复了记忆功能.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 行为科学 行为科学
背景情况:
- 吗啡戒断会导致与dynorphins相关的认知缺陷.
- 众所周知,运动可以改善认知功能,并调节内源性阿片类.
- 运动在通过dynorphins缓解吗啡戒断诱导的认知功能障碍方面的具体作用尚未完全理解.
研究的目的:
- 调查有氧运动预防和改善因吗啡戒断而导致的认知功能障碍的生理机制.
- 探索动诺芬及其受体在运动介导的认知恢复中的参与.
主要方法:
- 成年雄性C57BL/6小鼠被分配到控制,运动,吗啡戒断和运动与吗啡戒断组相结合的组.
- 建立了有氧运动模型,以评估预防和改善效果.
- 进行了行为测试 (开放场测试,时间顺序记忆测试,Y迷宫) 和分子分析 (西方斑点,免疫光).
主要成果:
- 练习组 (预防和改进) 在记忆和物体识别任务中表现正常,类似于对照组.
- 吗啡戒断显著改变了海马体和kappa阿片类受体1 (OPRK1) 中介前额叶皮质 (mPFC) 中的迪诺芬前体 (PDYN) 表达.
- 运动干预减少了海马体中的PDYN表达和mPFC中的OPRK1表达.
结论:
- 有氧运动有效地预防和改善与急性吗啡戒断相关的认知功能障碍.
- 这些好处是由海马体中PDYN和mPFC中OPRK1的下调调节的介导.
- PDYN和OPRK1代表了管理吗啡戒断引起的认知障碍的潜在治疗点.
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