thalamic亚区域的改变的静止状态功能连接在患有球的患者中
Yuanyuan Hu1,2, Jingjie Zhao3, Yuening Jin1,2
1CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
全球 (Globus Pharyngeus,GP) 患者表现出大脑连接的改变. 具体来说,在thalamic亚区域观察到功能连接性下降,这可能解释了喉块的感觉.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 全球 (Globus Pharyngeus,GP) 是一种与情绪困扰相关的体征症状.
- 确切的GP的原因是未知的,但它涉及一个喉块的感觉没有物理阻塞.
- 在体感和情绪处理中改变的大脑网络可能是GP症状的基础.
研究的目的:
- 在GP患者的thalamic亚区域研究静止状态功能连接 (rsFC).
- 为了探索rsFC异常和GP患者的症状严重程度之间的关系.
主要方法:
- 使用了休息状态功能磁共振成像 (rs-fMRI).
- 在31名GP患者和24名健康对照中分析了rsFC.
- 由于它们在感官和情绪处理中的作用,重点放在丘脑的子区域上.
主要成果:
- 患有GP的患者在右尾部丘脑 (rcTtha) 和中皮层 (MCC) 之间显著减少了rsFC.
- 在GP患者中,在右面形 (rrTtha) 和左脑小脑之间也发现了rsFC的显著下降.
- rcTtha-MCC连接的异常与体化症状严重程度相关,但与抑郁或焦虑水平无关.
结论:
- 这项研究表明,在患有Globus Pharyngeus的个体中,thalamic亚区域的rsFC发生变化.
- 这些发现为GP.G.的病变产生提供了洞察力.
- 识别这些神经相关物可能有助于制定更好的诊断和治疗策略.
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