饮食质量,饮食炎症潜力和前列腺癌风险等级重新分类
Zhuo Tony Su1, Mufaddal Mamawala1, Patricia K Landis1
1The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA oncology
|October 17, 2024
概括
坚持饮食指南可能会降低在积极监测中的男性前列腺癌进展风险. 较高的健康饮食指数 (HEI) 分数与降低的等级重新分类有关,特别是对攻击性的形式.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 在积极监测期间,前列腺癌再分类等级风险与饮食的关系尚未完全理解.
- 饮食模式可能会影响癌症的进展,需要对其在积极监测管理中的作用进行调查.
研究的目的:
- 评估饮食质量和饮食炎症潜力与积极监测中的男性前列腺癌等级重新分类之间的关联.
主要方法:
- 一项前性队列研究,对886名患有前列腺癌1级 (GG) 的男性进行了积极监测.
- 通过验证的食物频率问卷评估饮食摄入量,分析遵守指南 (健康饮食指数 - HEI) 和炎症潜力 (饮食炎症指数 - DII).
- 竞争风险回归用于分析与等级重新分类 (GG2+和GG3+) 的关联,以预后因素进行调整.
主要成果:
- 较高的基线HEI和能源调整HEI (E-HEI) 评分与重新分类到GG2或更高等级的风险较低有显著的相关性.
- 更高的HEI和E-HEI分数也显示出与极端等级重新分类 (至GG3或更高) 风险降低的显著关联.
- 在饮食炎症指数 (DII) 或能量调整后的DII (E-DII) 和两种等级重新分类结果之间没有发现显著的关联.
结论:
- 通过HEI评分来衡量美国饮食指南的更高遵守,可能与积极监测中的男性前列腺癌等级重新分类的风险降低有关.
- 这些发现表明,饮食质量,特别是遵守一般健康饮食建议,可能在管理低风险前列腺癌方面发挥作用.
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