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检测,模式和结果的复发性HPV阳性口腔甲状腺状细胞癌

Rema Shah^1,2, Sarah G Wilkins^1,2, Conrad W Safranek^1,2

¹Yale University School of Medicine, New Haven, Connecticut.

JAMA otolaryngology-- head & neck surgery

|October 17, 2024

概括

复发的人类乳头瘤病毒 (HPV) 阳性口腔状细胞癌 (OPSCC) 影响10.1%的患者,通常通过症状检测,而不是成像. 为了找到最佳的监控策略,还需要进一步的研究.

科学领域:

在瘤学瘤学.
耳鼻喉科耳鼻喉科耳鼻喉科
放射学放射学是一门学科.

背景情况:

复发性人类乳头瘤病毒 (HPV) 阳性口腔状细胞癌 (OPSCC) 是一种罕见但严重的疾病,数据有限.
现有的关于HPV阳性OPSCC复发的研究还没有系统地分析治疗后监视成像策略或检测方法.

研究的目的:

改进对HPV阳性OPSCC中复发模式的理解.
为制定最佳的成像监测策略提供信息,以进行治疗后的随访.

主要方法:

以第三级护理医院的电子病历作为回顾性队列研究.
从2012年至2019年期间接受OPSCC治疗的患者的数据分析,重点关注HPV阳性病例.
从2022年12月到2023年5月进行的数据分析.

主要成果:

在367名HPV阳性OPSCC患者中,有10.1%的患者经历了真正的疾病复发.
局部,区域或局部和区域复发 (LRR) 在56.8%的复发病例中发生,而远程转移 (DM) 在40.5%中发生.
复发主要通过患者报告的症状 (81.1%) 而不是监视成像 (8.1%) 检测到.

结论:

在HPV阳性OPSCC中,真正的疾病复发发生在10.1%的病例中,远程转移经常涉及肺和大脑.
目前的监测方法似乎不足,因为大多数复发是通过症状变化来识别的,而不是常规成像.
对最佳监测策略的进一步调查是有必要的,以改善复发性HPV阳性OPSCC的早期检测.

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