探索糖尿病神经病变中坐骨神经病变的结构和分子特征:揭示致病途径和点
Daniel Schwarz1, Maxime Le Marois2, Volker Sturm1
1Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Diabetes
|October 17, 2024
概括
坐骨神经中的糖尿病神经病变 (DN) 显示结构损伤和血液神经屏障受损. 这些受损的囊缺乏神经保护,并表现出补充激活,这表明了DN的新治疗点.
科学领域:
- 神经科学是一个神经科学.
- 病理学 病理学 病理学
- 生物化学 生物化学
背景情况:
- 糖尿病神经病变 (DN) 是2型糖尿病 (T2D) 的常见并发症.
- 周围神经中的受伤 (LFs) 与DN症状严重程度有关.
- 了解LFs的结构和分子基础对于DN病变发生至关重要.
研究的目的:
- 描述糖尿病神经病变中受损囊的结构和分子组成.
- 为了研究血液神经屏障 (BNB) 在DN病变发生中的作用.
- 为了确定DN的潜在治疗点.
主要方法:
- 在T2D和非T2D捐赠者身上,ex vivo磁共振神经图像和体外阴部神经成像.
- 蛋白质组学分析,以比较受损和无损带的分子组成.
- 评估轴突完整性,髓化和血液神经屏障完整性.
主要成果:
- 病变仅在T2D捐赠者中发现,表现为轴突退化,脱髓化和BNB受损.
- 在T2D捐赠者中,非损伤的囊表现出神经保护通路的激活,而在LF中则没有这种激活.
- 线表现出经典补充通路激活的增加,并含有来自肝脏的急性阶段蛋白质,表明BNB中断.
结论:
- 糖尿病神经病变涉及结构性神经损伤和血神经屏障功能障碍.
- 在DN中受损的束的特征是缺乏神经保护和增加补体激活.
- 破坏BNB可能会促进有害的肝神经器官间通信,为DN提供新的治疗途径.
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