精神分裂症,非标签抗精神病药物和艾滋病毒感染者的痴呆风险
Joseph Magagnoli1,2, Tammy H Cummings1,2, Michael D Wyatt3
1Dorn Research Institute, Columbia VA Health Care System, Columbia, SC.
Journal of acquired immune deficiency syndromes (1999)
|October 17, 2024
概括
患有精神分裂症或使用抗精神病药物的HIV感染者 (PLWH) 面临更高的痴呆风险. 艾滋病毒感染本身也独立地增加了痴呆症风险,强调了全面护理的必要性.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症等并发症和抗精神病药物等药物可能会影响艾滋病毒感染者 (PLWH) 痴呆风险.
- 了解这些关联对于管理PLWH的认知健康至关重要.
研究的目的:
- 评估艾滋病毒患者与精神分裂症之间的关联,非标签抗精神病药物的使用,以及患痴呆症的风险.
- 为了确定艾滋病毒感染是否独立地导致痴呆风险升高.
主要方法:
- 使用美国退伍军人事务部医疗保健设施 (2000-2023) 的数据进行了一项回顾性队列研究.
- 包括精神分裂症的PLWH,非标签抗精神病药物使用的PLWH和没有这些疾病的PLWH.
- 使用与倾向分数匹配的非艾滋病毒对照,并使用Cox比例危险模型估计痴呆风险.
主要成果:
- 与没有精神分裂症或不使用抗精神病药物的HIV患者相比,患有精神分裂症的PLWH患有痴呆症的风险高出2.49倍 (HR=2.49).
- 使用非标签抗精神病药物的PLWH显示,痴呆的风险增加1.77倍 (HR=1.77).
- 艾滋病毒感染独立地与1.47倍更高的痴呆风险相关 (HR=1.47),即使在没有精神分裂症或抗精神病药物使用的患者中也是如此.
结论:
- 精神分裂症史和非标签抗精神病药物的使用与PLWH中痴呆发病率的增加有显著联系.
- 艾滋病毒感染本身是痴呆风险升高的独立风险因素.
- 研究结果强调了心理健康,药物和艾滋病毒在认知衰退中的复杂相互作用.
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