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在基因代码操纵方面达到新的高度,使用高通量查

Briana R Lino1, Sean J Williams1, Michelle E Castor1

  • 1Chemical and Biological Engineering Department, Tufts University, Medford, Massachusetts 02155, United States.

Chemical reviews
|October 17, 2024
PubMed
概括

遗传密码的扩展使得非正规氨基酸 (ncAAs) 可以被纳入蛋白质中,从而增强其功能. 高通量选加速了新型ncAA含有蛋白质的发现,具有多种应用.

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Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...