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在1型糖尿病的非常年幼儿童中使用18个月的混合闭环:单臂多中心试验
Julia Ware1,2, Janet M Allen1,2, Charlotte K Boughton1,3
1Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, U.K.
Diabetes care
|October 17, 2024
概括
混合闭环 (CL) 疗法改善了1型糖尿病 (T1D) 的非常年幼儿童的血糖控制超过18个月. 这种先进的系统在这个年龄组的T1D管理中证明了持续的有效性和安全性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生物医学工程 生物医学工程
- 糖尿病 技术 技术
背景情况:
- 在非常年幼的儿童中,1型糖尿病 (T1D) 的管理带来了独特的挑战.
- 混合闭环 (CL) 系统为改善血糖控制提供了一个潜在的解决方案.
- 这种人群中对CL治疗的长期数据有限.
研究的目的:
- 评估混合性CL治疗在1至7岁患有T1D的儿童的延长安全性和疗效.
- 为了比较CL治疗在18个月的延长阶段与初始传感器增强 (SAP) 和CL期间的结果.
主要方法:
- 一个跨国随机交叉试验之后,使用CL治疗进行了为期18个月的延长阶段.
- 参与者 (n=49) 年龄为1至7岁,患有T1D,在初级阶段后继续进行CL治疗,将CL与SAP进行比较.
- 包括时间在范围 (TIR) 和HbA1c在内的结果在研究期间之间进行了比较.
主要成果:
- 与初级SAP阶段相比,CL治疗延期阶段的TIR显著提高 (+8.4%) 和HbA1c降低 (-0.4%).
- 血糖控制指标 (HbA1c,TIR) 在CL延长期和初级CL期间保持稳定和可比.
- 低血糖的时间在所有时期都是相似的;报告了两个严重的低血糖事件和一个严重的不良装置效应.
结论:
- 剑桥混合CL系统在T1D的非常年幼儿童中提供了持续的血糖控制效益超过18个月.
- 混合CL治疗是一种安全有效的选择,用于在学龄前儿童中管理T1D.
- 持续使用CL技术支持长期改善儿科患者的糖尿病管理.
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