脂肪组织对压力诱导的免疫抑制做出反应,部分通过miR-145-5p/S1PR1通路影响免疫反应
Xiangnan Wang1, Yi Jiang1, Yuxin Zhang1
1College of Life Science and Technology, Harbin Normal University, Harbin 150001, PR China.
Poultry science
|October 17, 2024
概括
在中,压力诱导的免疫抑制通过影响脂肪组织中T细胞迁移来损害免疫反应. 确定了miR-145-5p/S1PR1通路作为一个关键的调节器,循环中的miR-145-5p显示出作为生物标记物的潜力.
科学领域:
- 禽类免疫学 禽类免疫学
- 脂肪组织生物学 脂肪组织生物学
- 免疫调节的分子机制
背景情况:
- 压力诱导的免疫抑制 (SIIS) 是家禽生产的一个重要问题,导致疾病易感性和经济损失.
- 脂肪组织在免疫力中的作用越来越被认可,但其在SIIS中的具体参与仍然不太清楚.
- 了解脂肪组织如何影响压力期间的免疫反应,对于改善家禽健康至关重要.
研究的目的:
- 为了研究T细胞迁移和在不同免疫状态下在肉脂肪组织中的sphingosine-1-phosphate受体1 (S1PR1) 基因表达之间的动态关系.
- 阐明脂肪组织有助于SIIS并影响免疫反应的机制,特别是对纽卡斯尔病病毒 (NDV).
- 探索循环微RNA作为SIIS生物标志物的潜力.
主要方法:
- 动态分析T细胞迁移和S1PR1基因表达在的脂肪组织,从不同的免疫状态的模型.
- 评估SIIS对纽卡斯尔病病毒 (NDV) 免疫反应的影响.
- 研究miR-145-5p/S1PR1通路在调节脂肪组织内的T细胞迁移中的作用.
主要成果:
- SIIS显著改变了与淋巴细胞迁移相关的S1PR1基因的表达.
- SIIS通过影响脂肪组织中TCRα+ T细胞的迁移和增殖,部分抑制了NDV免疫反应.
- 确定miR-145-5p/S1PR1通路是脂肪组织中T细胞迁移的关键调节机制,循环miR-145-5p显示出作为分子标记物的潜力.
结论:
- 脂肪组织在调节T细胞迁移和在中因压力诱导的免疫抑制过程中的免疫反应中发挥着关键作用.
- miR-145-5p/S1PR1通路是家禽中SIIS的重要分子机制.
- 循环的miR-145-5p可以作为评估中的SIIS的有价值生物标志物,为家禽健康管理提供创新的见解.
更多相关视频
06:28Isolation and Culture of Human Mature Adipocytes Using Membrane Mature Adipocyte Aggregate Cultures MAAC
Published on: February 13, 2020
19.0K
06:08Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
Published on: May 19, 2023
2.0K
相关概念视频
Hypothalamic-Pituitary Axis
59.5K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.5K
Psychoneuroimmunology: Diabetes and Cancer
24
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
24
Stress Response System
66
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
66
Physiological Foundation of Stress
48
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
48
