在热量限制饮食干预中,肠道胰腺激素的变化与干预后的体重维持有关
Huibin Lin1, Qiaoling Wang1, Aibo Gao2
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
卡路里限制会改变食欲激素,如氨酸和GLP-1. 饮食期间显著的荷尔蒙变化预测干预后的体重维持不佳,无论饮食类型如何.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 卡路里限制 (CR) 是一种常见的体重管理策略.
- 了解对CR的荷尔蒙反应对于长期成功至关重要.
- 个人对CR的反应可能会有所不同,因此需要对预测生物标志物的研究.
研究的目的:
- 为了研究在同位热量限制饮食期间肠道胰腺激素的变化.
- 确定这些荷尔蒙变化对干预后体重维持的影响.
- 评估CR期间的荷尔蒙特征是否可以预测重量恢复.
主要方法:
- 253名超重/肥胖和糖尿病前期的参与者被随机分配到三种25%的同热量限制饮食 (控制,传统江南,地中海).
- 血清激素水平和临床指数在基线,3个月和6个月测量.
- 在干预完成6个月后,重新评估了体重.
主要成果:
- CR导致葡萄糖,氨酸,YY和葡萄糖类-1 (GLP-1) 的水平降低,并增加了 ghrelin.
- 在6个月的干预期间,这些荷尔蒙变化在很大程度上持续了下去.
- 在CR期间,氨基林/GLP-1的较大降低或林的增加与干预后更大的体重恢复有关.
结论:
- 卡路里限制会导致持续的荷尔蒙变化,无论饮食模式如何.
- 在CR期间氨酸,GLP-1和胆固醇的变化可以作为预测体重维持的潜在生物标志物.
- 节食期间的荷尔蒙反应可能会为长期的体重管理成功提供见解.
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