性别,疫苗接种情况和并发症影响COVID的长期持久性
Trevon Fuller1, Roxana Flores Mamani2, Heloísa Ferreira Pinto Santos3
1Acute Febrile Illnesses Laboratory, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, Cep: 21.040-360 RJ, Brazil.
Journal of infection and public health
|October 17, 2024
概括
在21%的参与者中,长期COVID症状持续数月,疲劳是最常见的. 女性性别,缺乏疫苗接种和并发症增加了长期COVID风险.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 长期COVID,定义为SARS-CoV-2感染后的持续症状,构成了重大的公共卫生挑战.
- 了解人口和临床风险因素对于管理长期COVID至关重要,特别是在中高收入国家 (UMICs).
研究的目的:
- 确定长期COVID的发展和持续性的人口和临床风险因素.
- 探索潜在的生物标志物,如IgG抗体标位,可以预测随时间推移的症状轨迹.
主要方法:
- 一项前性队列研究与在Omicron变异激增期间经历轻度SARS-CoV-2感染的成年人进行.
- 随着时间的推移,对抗SARS-CoV-2尖端S1亚单元的症状持续性和IgG抗体标位进行了监测.
主要成果:
- 在276名受感染的参与者中,21%的人经历了长期COVID症状≥2个月,5%的人经历了≥12个月.
- 疲劳,上呼吸道问题和肌痛/关节痛是最常见的持续症状.
- 持续性风险因素包括女性性别,不完整的疫苗接种和先前存在的并发病. 较低的抗S1IgG标位与持续的疲劳相关.
结论:
- 症状持续性在急性感染后降低,但5%的人没有完全康复.
- 女性,并发症患者和未接种疫苗的人面临更高的长期COVID风险,即使在高度接种疫苗的人群中.
- 免疫球蛋白水平显示为长期COVID疲劳的生物标志物具有潜力.
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