年轻成年人直肠癌:一个单一的中心体验
Halil Göksel Güzel1, Murat Koçer1, Mustafa Yıldız1
1Department of Medical Oncology, Antalya Training and Research Hospital, Antalya, Turkey.
Journal of adolescent and young adult oncology
|October 17, 2024
概括
年轻成年人 (40岁以下) 的直肠癌通常在晚期被诊断出来,患病率很高,存活率很低. 低意识和攻击性瘤类型有助于诊断延迟在这个人口.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 大肠直肠癌 (CRC) 在40岁以下的人群中不太常见,占病例的3%-11%
- 年轻人的直肠癌带来了独特的临床病理学挑战.
- 了解这些特征对于早期检测和改善结果至关重要.
研究的目的:
- 对40岁及以下的患者直肠癌的临床病理学特征进行审查.
- 确定导致年轻成年人诊断延迟和疾病晚期的因素.
- 分析这种特定患者群体的治疗结果和生存率.
主要方法:
- 进行了一项单臂描述性研究.
- 包括85名年龄在40岁以下的直肠腺癌患者,来自安塔利亚培训和研究医院.
- 分析了临床病理学数据,治疗细节和生存结果.
主要成果:
- 平均年龄为37岁;11.8%的患者患有粘膜腺癌或印记细胞癌.
- 24.4%的人患有高度癌症,16.5%的人有CRC家族史.
- 48.2%的人被诊断为第三阶段,27.1%的人被诊断为第四阶段;没有人通过查被诊断出来.
- 非转移性患者的5年无病生存率为69.7%.
- 在转移性患者中,KRAS突变率为56.5%,平均整体存活时间为22.3个月.
结论:
- 年轻人的直肠癌经常在晚期被诊断出来,这与之前的报道一致.
- 诊断延迟可能源于年轻患者和护理人员对癌症的认识较低,以及瘤组织学的攻击性.
- 需要进一步的研究,以充分阐明这一人口中晚期诊断的原因.
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