通过使用全细胞Rhizopus oryzae脂酶生成的 peracids,有效地将 (R) - - - - 烯氧化成二氧化
Lili Xu1, Qingqing Zhao2, Haibo Liu3
1Medical College, Guangxi University, Nanning 530004, China; College of Marine Sciences, Beibu Gulf University, Qinzhou 535011, China; School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
Bioresource technology
|October 17, 2024
概括
这项研究介绍了一种化学酶方法,用于使用Rhizopus oryzae生产二氧化 (LDO). 优化条件实现了93%的LDO产量,这对于生物基聚合物至关重要.
科学领域:
- 生物催化剂是一种生物催化剂.
- 绿色化学 绿色化学
- 聚合物科学 聚合物科学
背景情况:
- 二氧化 (LDO) 是合成生物基聚碳酸盐和非异酸盐聚氨的一个关键单体.
- 高效和选择性的LDO生产对于推动可持续的聚合物制造至关重要.
研究的目的:
- 开发一种化学酶策略,以高产量,选择性氧化 (R) - - - +) - - 烯到LDO.
- 为了优化双氧化反应的反应条件,克服中间水解等挑战.
主要方法:
- 使用Rhizopus oryzae的整个细胞进行 (R) - ((+)) - 烯的化学酶氧化.
- 优化反应参数,包括过氧化度和使用三酸盐.
- 研究了酸在防止中间水解和促进双重氧化中的作用.
主要成果:
- 在20小时内实现了二氧化 (LDO) 93%的高产量.
- 证明了Rhizopus oryzae全细胞的有效性,甚至超过了以前报告的使用固定酶的方法,如Novozym 435.
- 在优化条件下消除了中间产品1,2-烯氧化物的形成.
结论:
- 使用Rhizopus oryzae全细胞开发的化学酶过程提供了一条有效的路径到二氧化 (LDO).
- 优化条件,包括足够的酸和受控的过氧化物水平,对于高产量的双重氧化是至关重要的.
- 这种方法为生产生物基聚合物必需的单体提供了可持续的途径.
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